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pchR [2017-05-24 12:27:35]
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pchR [2017-05-24 12:27:35]

transcriptional repressor (MarR family), controls the expression of genes involved in pulcherriminic acid biosynthesis
locus
BSU35080
pI
8.09
mw
19.54 kDa
protein length
169 aa Sequence Blast
gene length
507 bp Sequence Blast
function
control of pulcherriminic acid biosynthesis
product
transcription factor (MarR family)
essential
no
synonyms
yzhA,yvmB
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other]

    • Gene

    Coordinates
    3,604,993 → 3,605,502

    Phenotypes of a mutant

  • inactivation of ''[gene|0D555F2AB7DC863E6FF388888308E980514DB719|pchR]'' causes widespread disruption of proteins involved in cellular processes that depend on iron availability, with pleiotropic effects on proteins associated with carbon metabolism, translation, stress response, biosynthesis of cell wall, and sporulation initiation [Pubmed|27542896]

    • The protein

    Protein family

  • MarR family of transcriptional regulators [Pubmed|27542896]

    • Additional information

  • Proposed consensus sequence for DNA-binding site: GTTYMMYMGTAAAC [Pubmed|27542896]

    • Expression and Regulation

    Operons

    genes
    [gene|0D555F2AB7DC863E6FF388888308E980514DB719|pchR]-[gene|7F10DEEDEF8B679F4F2C5EAD5752F4E399DB0D57|yvmA]
    description
    [Pubmed|22383849]

    regulatory mechanism

  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|12850135]; [protein|0D555F2AB7DC863E6FF388888308E980514DB719|PchR] auto-repression [Pubmed|27542896], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]
  • [protein|0D555F2AB7DC863E6FF388888308E980514DB719|PchR]: repression, in [regulon|0D555F2AB7DC863E6FF388888308E980514DB719|PchR regulon]

    • regulation

  • induced by iron starvation [Pubmed|27542896]
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    Biological materials

    Mutant

  • BKE35080 ''pchR''::''erm trpC2'' is available from the Bacillus Genetic Stock Center
  • CS217 (''[gene|0D555F2AB7DC863E6FF388888308E980514DB719|pchR]''::''aphA3'', available in [SW|Colin Harwood]'s and [SW|Jörg Stülke]'s labs) [Pubmed|27197833]

    • Labs working on this gene/protein

  • Sandrine Auger, Micalis Institute, INRA, AgroParisTech, France

    • References

  • 12850135,22383849,27542896,27197833